Oxygen-containing cyclohexane derivative and preparation method and application thereof

The invention discloses an oxygen-containing cyclohexane derivative, the structural formula of which is as shown in the specification. In the structural formula, R1, R2, R3, R4 and R5 are respectivelyone of hydrogen, benzoyl and ethyl. The invention also discloses a preparation method of the preferred compound and application of the preferred compound in preparation of anti-rheumatoid arthritis drugs. The activity of the oxygen-containing cyclohexane derivative in inhibition of rheumatoid arthritis synovial cell proliferation is discovered for the first time, and the oxygen-containing cyclohexane derivative can be used for preparing anti-rheumatoid arthritis drugs. 本发明公开了一种含氧环己烷衍生物，其结构式如下，其中R、R、R、R、R分别为氢、苯甲酰基、乙基中一种。本发明还公开了优选化合物的制备方法和其在制备抗类风湿关节炎药物中的应用。本发明首次发现了含氧环己烷衍生物在抑制类风湿关节炎滑膜细胞增殖中的活性，可用于制备抗类风湿关节炎的药物。