RECOMBINANT VACCINE AGAINST PROLIFERATIVE ENTEROPATHY IN ANIMALS

The present invention relates to a recombinant vaccine against Lawsonia intracellularis, based on a recombinant synthetic chimeric variant of membrane proteins and invasins of said bacteria. In addition, the invention discloses synthetic nucleotide sequences encoding said protein variants, recombinant proteins as such, an expression cassette of said synthetic protein antigens, a transformed cell,and a method for producing said antigens, demonstrating the antigenicity and protective potential thereof against the pathogen Lawsonia intracellularis. 本发明涉及一种对抗胞内劳森氏菌的重组疫苗，其基于所述细菌的膜蛋白和侵袭素的重组合成嵌合变体。另外，本发明还公开了编码所述蛋白变体的合成核苷酸序列，重组蛋白，所述合成蛋白抗原的表达盒，转化细胞以及产生所述抗原的方法，证明了其对病原体胞内劳森氏菌的抗原性和保护潜力。