Oxoacridinyl acetic acid derivatives and methods of use

Oxoacridinyl acetic acid derivatives and methods of use

Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided. 提供了能够与干扰素基因刺激...

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Bibliographische Detailangaben
Hauptverfasser: SHERMAN WOODY, CHAMBERLAIN BRIAN T, SHECHTER SHARON, MARINO KRISTEN A, RICE JAMES M, JERNIGAN FINITH E III, ALLEN BRYCE K, LIN ZHIXIONG, KULKARNI MEGHANA M, TAN DAZHI
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided. 提供了能够与干扰素基因刺激蛋白(STING)结合并调节其活性的式I化合物或其药学上可接受的盐或酯。还提供了涉及式I化合物作为STING有效调节剂的方法。