Preparation method of terbinafine hydrochloride
The invention provides a preparation method of terbinafine hydrochloride, which comprises the steps of: carrying out a substitution reaction on N-methyl-1-naphthylamine (II) and (E)-1, 3-dichloropropene (III) in an acid-binding agent A to obtain an N-(3-chloroallyl-1)-methyl-1-naphthylamine (IV) rea...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a preparation method of terbinafine hydrochloride, which comprises the steps of: carrying out a substitution reaction on N-methyl-1-naphthylamine (II) and (E)-1, 3-dichloropropene (III) in an acid-binding agent A to obtain an N-(3-chloroallyl-1)-methyl-1-naphthylamine (IV) reaction liquid; carrying out condensation reaction on N-(3-chloroallyl-1)-methyl-1-naphthylamine (IV)and 3, 3-dimethyl-1-butyne (V) in the reaction solution under the action of a composite catalyst and an acid-binding agent B to obtain a reaction solution of (E)-N-(6, 6-dimethyl-2-heptene-4-alkynyl)-N-methyl-1-naphthylamine (VI); complexing and washing the reaction solution with ammonia water to obtain an oily substance; and salifying the oily substance in a hydrochloric acid aqueous solution toobtain crude terbinafine hydrochloride, and recrystallizing the crude terbinafine hydrochloride to obtain terbinafine hydrochloride. The preparation method disclosed by the invention does not use an organic solvent, is environ |
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