Macrocyclic diterpenoid compounds separated from Euphorbia glomerulans and preparation method and application thereof

The invention relates to macrocyclic diterpenoid compounds separated from Euphorbia glomerulans as well as a preparation method and application thereof. The preparation method comprises the followingsteps: subjecting whole grass of Euphorbia glomerulans (E. glomerulans) as a raw material to extraction with organic solvents, and performing separation by three to four methods of a solvent extraction method, a normal-phase silica gel column chromatography method, a reverse-phase silica gel column chromatography method and a Sephadex LH-20 gel column chromatography method to obtain three novel Jatrophane macrocyclic diterpenoid compounds shown as a formula (I), a formula (II) and a formula (III). The three novel compounds are subjected to anti-tumor multidrug resistance reversion activity tests, and results show that the three novel Jatrophane macrocyclic diterpenoid compounds shown in the formula (I), the formula (II) and the formula (III) have different degrees of anti-tumor multidrug resistance reversion activ