Salifying purification method of oxagolide intermediate and obtained oxagolide intermediate refined product

The invention relates to the field of pharmacy, in particular to a salifying purification method of an oxagolide intermediate and an obtained oxagolide intermediate refined product, and the salifyingpurification method comprises the following steps: (1) dissolving an oxagolide intermediate crude pro...

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Hauptverfasser: LIANG JINQIAN, ZHOU TIANXI, CHE FENGFENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of pharmacy, in particular to a salifying purification method of an oxagolide intermediate and an obtained oxagolide intermediate refined product, and the salifyingpurification method comprises the following steps: (1) dissolving an oxagolide intermediate crude product in a benign solvent, and then adding an organic acid for salifying; (2) dropwise adding the solution into a poor solvent, and stirring to separate out a solid; (3) filtering and drying to obtain an organic acid salt of the high-purity oxagolide intermediate; (4) dissolving the salified solid in an ester or halogenated alkane solvent, adding a sodium hydroxide solution to adjust the pH value to 9, and extracting and layering to remove organic acid to obtain an organic layer; and (5) concentrating the organic layer to obtain a high-purity oxagolide intermediate refined product. According to the invention, complex purification steps are avoided, operation is easy and convenient, the process repeatability is good,