Preparation method of imidocarb dipropionate and intermediate thereof

The invention discloses a preparation method of imidocarb dipropionate and an intermediate thereof and belongs to the technical field of chemical pharmacy. According to the method, m-nitrobenzonitrilereacts with ethylenediamine with sodium sulfide taken as a catalyst; palladium on carbon-ammonium formate reduction is performed; a product and urea are subjected to condensation reaction, so that imidazole phenylurea dihydrochloride can be obtained; dissociated imidazole phenylurea reacts with propionic acid, so that the imidazole phenylurea dipropionate can be obtained. The method has the advantages o reduced wastes, cheap and easily available raw materials, simple operation, high product yield, simple process operation and high safety, and is suitable for industrial production. 本发明公开了一种二丙酸咪唑苯脲及其中间体的制备方法。属于化学制药技术领域。方法是将间硝基苯甲腈以硫化钠为催化剂与乙二胺反应，再经过钯碳甲酸铵还原，与尿素缩合反应制得咪唑苯脲二盐酸盐，游离出咪唑苯脲与丙酸反应制得二丙酸咪唑苯脲。本发明减少了废弃物的产生，原料廉价易得，操作简便，产品收率高，工艺操作简便，安全性高，适合工业化生产。