Preparation process of captopril tablets

The invnetion discloses a preparation process of captopril tablets. The captopril tablets are prepared from the following components in percentage by weight: captopril, a filling agent, a disintegrating agent, a lubricating agent and an adhesive, and the captopril tablets are prepared by weighing, s...

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Bibliographische Detailangaben
Hauptverfasser: LIN FANRU, WANG MEICHENG, LIU YONG, MAO CHUANWEI, GUO ZENGGUANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invnetion discloses a preparation process of captopril tablets. The captopril tablets are prepared from the following components in percentage by weight: captopril, a filling agent, a disintegrating agent, a lubricating agent and an adhesive, and the captopril tablets are prepared by weighing, sieving, mixing and directly tabletting by using compressible auxiliary materials. According to the method, the content of hydrolysis impurity captopril disulfide in captopril is reduced, and the dissolution speed is increased. The method has the characteristics of simple production process, cost saving, good stability and the like. 本发明公开了一种卡托普利片的制备工艺,该片由下列重量百分比的组分制成:卡托普利、填充剂、崩解剂、润滑剂、粘合剂,经过称配、过筛、混合,使用可压辅料直接压片制备卡托普利片。本发明降低了卡托普利中水解杂质卡托普利二硫化物的含量,提高了溶出速度。本发明生产工艺简单、节约成本、稳定性好等特点。