Thioether compound, preparation method thereof, medical intermediate and application thereof

The invention relates to the technical field of chemical synthesis, and particularly discloses a thioether compound, a preparation method of the thioether compound, a medical intermediate and application of the medical intermediate, and the thioether compound is prepared from the following raw mater...

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Bibliographische Detailangaben
Hauptverfasser: ZHU SHENGZHEN, CHEN DENGFENG, MENG XIANGTAI, ZHANG YINGYIN, LUO JINYUE, FU YUANYUAN, HUANG SHENLIN, LIU CHENJING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of chemical synthesis, and particularly discloses a thioether compound, a preparation method of the thioether compound, a medical intermediate and application of the medical intermediate, and the thioether compound is prepared from the following raw materials: a sulfoxide compound, a bromide and 1-butyl-3-methylimidazole trifluoromethanesulfonate. The thioether compound provided by the invention is reacted in ionic liquid 1-butyl-3-methylimidazole trifluoromethanesulfonate, a metal catalytic reaction is not needed, the problems of metal residues, organic solvent pollution and the like are fundamentally eliminated, and the thioether compound is particularly suitable for synthesis of some medicines and has relatively high economic applicability. The preparation method provided by the invention has the advantages of simple operation, high yield, high product purity, no need of metal catalysis in the whole reaction, mild reaction conditions andwide substrate range, sol