Method for synthesizing 2, 4-difluoro-3-trimethylacetamido benzoic acid

The invention discloses a method for synthesizing 2, 4-difluoro-3-trimethylacetamido benzoic acid, which belongs to the field of organic synthesis, and comprises the following steps: reacting 2, 6-difluoroaniline with pivaloyl chloride under the action of an alkali to obtain N-(2, 6-difluorophenyl) trimethylacetamide; carrying out bromination reaction on N-(2, 6-difluorophenyl) trimethylacetamideto obtain N-(3-bromo-2, 6-difluorophenyl) trimethyl acetamide; preparing 2, 4-difluoro-3-trimethylacetamido benzoic acid from N-(3-bromo-2, 6-difluorophenyl) trimethyl acetamide; the method disclosedby the invention has the advantages of cheap and easily available raw materials, no use of various precious catalysts, short synthesis steps, low cost, high total yield, no need of special equipment such as ultra-high temperature reaction and the like, high production safety coefficient, environmental friendliness, suitability for industrial production and the like. 本发明公开了一种合成2,4-二氟-3-三甲基乙酰胺基苯甲酸的方法，属于有机合成领域，包括以下步骤：使2,6-二氟苯