Application of osteopontin for adjusting flora structure in in-vitro culture process of intestinal flora

The invention discloses an application of osteopontin for adjusting a flora structure in an in-vitro culture process of intestinal flora. The osteopontin is added into a culture medium of the intestinal flora to serve as a culture medium component. When the OPN is added into the culture medium, the intestinal flora obtained by in-vitro culture is more similar to the initial flora structure, whichis mainly reflected in that the flora types except the core flora are more similar to the original flora. Therefore, the intestinal flora obtained by in-vitro culture can be subsequently applied to research in the fields of human intestinal metabolism, genetic characteristics and functions of flora in microecology and the like. 本发明公开了骨桥蛋白在肠道菌群体外培养过程中调节菌群结构的应用：在肠道菌群的培养基中添加骨桥蛋白作为培养基组分。在添加OPN至培养基时，体外培养获得的肠道菌群与其初始的菌群结构更为相近，主要体现在除核心菌群以外的菌群种类与原始菌群更相近。这将有利于后续将体外培养获得的肠道菌群应用于人体肠道代谢、微生态中菌群的遗传特性及功能等领域的研究。