Indole triarylmethane derivative and synthesis method thereof

The invention discloses a method for synthesizing an indole triarylmethane derivative. The indole triarylmethane derivative is synthesized through a one-pot reaction of salicylaldehyde, aromatic boricacid and indole by taking ferric trichloride as a catalyst. The three different aryl groups are intr...

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Hauptverfasser: XU DAZHEN, YU YAQIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for synthesizing an indole triarylmethane derivative. The indole triarylmethane derivative is synthesized through a one-pot reaction of salicylaldehyde, aromatic boricacid and indole by taking ferric trichloride as a catalyst. The three different aryl groups are introduced from salicylaldehyde, arylboronic acid and indole which are low in price and easy to obtainin one step. The reaction has very high chemical selectivity, the reaction method is simple and convenient to operate, the reaction time is short, the catalyst is cheap and easy to obtain, the production cost is low, the pollution is less, the post-treatment is simple, and the reaction has very high yield. 本发明公开了一种合成吲哚三芳基甲烷衍生物的方法,它是以三氯化铁为催化剂,由水杨醛、芳香硼酸和吲哚"一锅"反应合成得到。这三种不同的芳基是由价格低廉且容易获得的水杨醛、芳基硼酸和吲哚一步引入的,该反应具有很高的化学选择性,反应方法操作简便,反应时间短,催化剂廉价易得,生产成本低,污染少,后处理简单,而且反应具有很好的收率。