CARBOXYESTERASE BIOCATALYSTS

The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, hostcells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineer...

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Bibliographische Detailangaben
Hauptverfasser:	HONICKER KATHERINE JOYCE, SCHOBER MARKUS, VOLADRI RAMA, BROWN KRISTIN K, DORR BRENT M, PLOTNIKOV NIKOLAY V, JORDAN LYDIA SANCHEZ, FUERST DOUGLAS E, MORRISON JAMES PATRICK
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, hostcells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes to make commercially valuable amides. Also provided are amides that aremade using the engineered carboxyesterase enzymes. 本公开内容提供了具有催化酰胺键形成的能力的工程化羧酸酯酶。还提供了编码羧酸酯酶的多核苷酸、能够表达工程化羧酸酯酶的宿主细胞、以及使用工程化羧酸酯酶制备商业上有价值的酰胺的方法。还提供了使用工程化羧酸酯酶制备的酰胺。