Preparation method of micron hydrogel with colon-specific delivery

The invention discloses a preparation method of micron hydrogel with colon-specific delivery. The preparation method comprises the following steps of dissolving puerarin and low-methoxy pectin in deionized water, carrying out stirring, dissolving, standing to remove bubbles, then sucking by using a microfluidic device water-phase sampler, and sucking mineral oil dissolved with span 80 by using anoil-phase sampler, wherein water-in-oil micron hydrogel generated by cutting of the microfluidic device flows out of the sample outlet and then enters a chitosan solution containing anhydrous zinc acetate, so that the pectin solution is demulsified and then is crosslinked with chitosan/zinc acetate. The micron hydrogel is used for embedding and releasing puerarin. The micron hydrogel prepared by the method has a colon-specific release effect. 本发明公开了一种具有结肠特异性递送的微米水凝胶制备方法，该将葛根素和低甲氧基果胶溶解于去离子水中，搅拌溶解静置去除气泡后用微流控装置水相进样器吸入，油相进样器吸入溶解有司盘80的矿物油，微流控装置切割产生的油包水微米水凝胶由出样口流出后进入含有无水醋酸锌的壳聚糖溶液中，使果胶溶液破乳后与壳聚糖/醋酸锌交联。将微米水凝胶用于葛根素的包埋与释放。该方法制备的