VACCINE AGAINST KLEBSIELLA PNEUMONIAE

The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugat...

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Bibliographische Detailangaben
Hauptverfasser:	PRZYGODDA JESSICA, PEREIRA CLANEY LEBEV, PARAMESWARAPPA SHARAVATHI GUDDEHALLI, LISBOA MARILDA P, OESTREICH SYLVIA, MONNANDA BOPANNA, VON BONIN ARNE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detectionof antibodies against Klebsiella pneumoniae bacteria. 本发明涉及与肺炎克雷伯菌血清型O1、O2、O2ac和O8 O-多糖和耐碳青霉烯的肺炎克雷伯菌ST258 O-多糖相关的通式(I)的合成糖及其缀合物。所述的合成糖、所述的缀合物和包含所述合成糖或所述缀合物的药物组合物可用于预防和/或治疗与肺炎克雷伯菌相关的疾病。此外，通式(I)的合成糖可用作检测抗肺炎克雷伯菌的抗体的免疫学测定法中的标记物。