Nucleic acid detection kit for quantifying trace residues of mouse source tissues

The invention discloses a nucleic acid detection kit for quantifying trace residues of mouse source tissues. The kit can detect the DNA residues of the mouse source tissues or cells, and the minimum concentration is 0.1 fg/[mu]l; the kit has the high specificity while having the high sensitivity, an...

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Hauptverfasser: SUN MINGDI, WANG BOWEI, CHEN TAO, LI YING, CHANG ZISONG, LI TING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a nucleic acid detection kit for quantifying trace residues of mouse source tissues. The kit can detect the DNA residues of the mouse source tissues or cells, and the minimum concentration is 0.1 fg/[mu]l; the kit has the high specificity while having the high sensitivity, and can be used for food pollution detection, environmental monitoring and precise quantification of the DNA residues of the mouse source cells in biological medicines such as monoclonal antibodies; and a reliable quality control evidence can be provided for production links of semi-finished productsand finished products of the biological medicines such as the monoclonal antibodies, and important guarantee is provided for safety production and use of vaccines. 本发明公开了一种定量小鼠源组织痕量残留的核酸检测试剂盒,本发明可以检测出小鼠源组织或细胞的DNA残留,最低浓度为0.1fg/μl,在具有非常好的灵敏度同时还具有很好的特异性,可以用于检测食品污染、环境监测,以及精确定量单抗等生物药品中小鼠源细胞残留DNA;可为单抗等生物药品半成品、成品等生产环节提供等提供可靠的质控证据,为安全生产与使用提供重要保障为疫苗安全生产与使用提供重要保障。