Eudistomins Y derivative with anti-tumor activity as well as preparation method and application of Eudistomins Y derivative

The invention discloses a Eudistomins Y derivative with anti-tumor activity as well as a preparation method and application of the Eudistomins Y derivative. A tryptamine derivative (i) is used as a raw material and is subjected to a feeding reaction with acetophenone derivatives (ii), I2 and H2O2 to obtain a compound represented by a general formula (iii), and the compound represented by the general formula (iii) is subjected to a feeding reaction with R-X and K2CO3 according to the molar ratio of 1:(2-6):(2-6) to obtain a compound represented by a general formula (I). The invention provides the Eudistomins Y derivative represented by a general formula (I) and a medically acceptable salt thereof. The Eudistomins Y derivative has the antitumor activity, and is obviously superior to an Eudistomin Y1 prototype compound in the aspect of inhibiting tumor cell proliferation; compared with the non-fluorescence activity of a natural Eudistomins Y compound, the Eudistomins Y derivative represented by the general formu