Application of small molecular substance in preparation of reagent for maintaining phenotype of tendon stem cells in vitro

Application of small molecular substance in preparation of reagent for maintaining phenotype of tendon stem cells in vitro

The invention provides application of a small molecular substance in preparation of a reagent for maintaining the phenotype of tendon stem cells in vitro, and belongs to the technical field of cell culture. The small molecular substance comprises one or more of SB939, CP-673451, lecithin, AZD2858, i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHANG YANJIE, YIN ZI, LEI TINGYUN, CHEN XIAO
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention provides application of a small molecular substance in preparation of a reagent for maintaining the phenotype of tendon stem cells in vitro, and belongs to the technical field of cell culture. The small molecular substance comprises one or more of SB939, CP-673451, lecithin, AZD2858, idarubicin hydrochloride, vincristine sulfate and vinblastine. The small molecular substance in the invention maintain the phenotype of the tendon stem cells in vitro by improving the expression level of tendon system specific genes and proteins. 本发明提供了小分子物质在制备体外维持肌腱干细胞表型的试剂中的应用，属于细胞培养技术领域，所述小分子物质包括SB939、CP-673451、卵磷脂、AZD2858、盐酸伊达比星、硫酸长春新碱和长春碱中的一种或几种。本发明中的小分子物质通过提高肌腱系特异基因和蛋白的表达水平，来体外维持肌腱干细胞表型。