NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF

The present invention relates to photo-activated compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA. 本发明涉及用于确定结合位点以及关于RNA转录物的其它结构信息的光激活化合物和其使用方法。本发明还提供识别结合化合物并且因此可药化的RNA转录物的方法、筛选药物候选物的方法和确定靶RNA上的药物结合位点和/或可接近或反应性位点的方法。