Chiral N-substituted-3, 3-difluoro-4-hydroxypiperidine derivative and preparation method thereof

The invention discloses chiral N-substituted-3, 3-difluoro-4-hydroxypiperidine, which is characterized in that the chiral N-substituted-3, 3-difluoro-4-hydroxypiperidine is a product of (I) or (II). The invention also discloses a preparation method thereof. According to the method, asymmetric reduction of the 3, 3-difluoro-4, 4-dihydroxy structure is realized for the first time, the operation is simple and convenient, the cost is low, industrial production of the optically pure 3, 3-difluoro-4-hydroxypiperidine derivative is facilitated, and the invention has the characteristic of environmental protection. 本发明公开了一种手性N-取代-3,3-二氟-4-羟基哌啶，其特征在于，所述的手性N-取代-3,3-二氟-4-羟基哌啶为(I)或(II)的产物。本发明还公开了其制备方法。本方法首次实现3,3-二氟-4,4-二羟基结构的不对称还原，操作简便，成本低廉，有助于光学纯3,3-二氟-4-羟基哌啶衍生物的工业化生产，具有绿色环保的特点。