Tiotropium solution for inhalation
The invention provides a tiotropium solution for inhalation. The tiotropium solution comprises tiotropium salt, single water or a water/ethanol mixture, acetylcysteine and other optional pharmacologically acceptable auxiliary materials, wherein the tiotropium salt is used as an active substance, and...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a tiotropium solution for inhalation. The tiotropium solution comprises tiotropium salt, single water or a water/ethanol mixture, acetylcysteine and other optional pharmacologically acceptable auxiliary materials, wherein the tiotropium salt is used as an active substance, and the concentration of the tiotropium salt is 0.0005-5% by weight based on tiotropium; the single water or the water/ethanol mixture is used as a solvent of the active substance; and the acetylcysteine is used as a stabilizer. The tiotropium solution has the beneficial effects that in the research and development process of the tiotropium solution, the condition that the storage of the tiotropium solution is more stable by adding 0.15-0.5% of the acetylcysteine is accidentally found, related substances of the preparation are reduced, and the safety and effectiveness of the medicine are guaranteed.
本发明提供一种用于吸入的噻托铵溶液剂,包括:噻托铵盐,作为活性物质,其浓度以噻托铵计,重量比0.0005%~5%;单独水或水/乙醇混合物,作为活性物质的溶剂;乙酰半胱氨酸,作为稳定剂;任选的药理学上可接受的其他辅料。本发明的有益效果是在噻托 |
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