Rapamycin derivant as well as preparation method and application thereof

The invention belongs to the field of medicines, in particular to a rapamycin derivant as well as a preparation method and application thereof. A structural formula of the rapamycin derivant is as follows: the formula is shown in the description. Through culturing of strains, culturing of seeds and transformation culturing, transformation is further carried out, so that the rapamycin derivant is obtained. According to the rapamycin derivant as well as the preparation method and the application thereof disclosed by the invention, through a microorganism transformation method, a new rapamycin derivant is obtained, and the new rapamycin derivant has an anti-tumor effect. At present, the compound is difficultly prepared through a chemical semisynthetic method. 本发明属于医药领域，尤其涉及一种雷帕霉素衍生物及其制备方法和应用。所述雷帕霉素衍生物，结构式如下：通过菌株培养、种子培养、转化培养，转化得到雷帕霉素衍生物。本发明通过微生物转化方法，获得新的雷帕霉素衍生物，具有抗肿瘤作用。该化合物目前很难通过化学半合成方法制备。