Synthesis method of 2-bromo-5-fluorobenzotrifluoride

The invention relates to a synthesis method of 2-bromo-5-fluorobenzotrifluoride. The synthesis method comprises the following steps: with benzotrifluoride as a raw material, mixing benzotrifluoride with sulfuric acid, potassium bromide, cuprous bromide and a catalyst, and carrying out a bromination reaction to obtain 2-bromobenzotrifluoride; putting the obtained 2-bromobenzotrifluoride into a DMSOsolvent, adding potassium fluoride and KCoF4, and carrying out a fluorination reaction so as to obtain 2-bromo-5-fluorobenzotrifluoride. According to the method, trifluorotoluene is used as the raw material; the method is a brand-new synthetic route; bromination and fluorination conditions are mild; reaction yield is high; used raw materials are easy to purchase and low in price; and thus, the method has relatively high industrial application value. 本发明涉及2-溴-5-氟三氟甲苯的合成方法，包括如下步骤：以三氟甲苯为原料，先将三氟甲苯和硫酸、溴化钾、溴化亚铜、催化剂混合，进行溴化反应得到2-溴三氟甲苯；将得到的2-溴三氟甲苯于DMSO溶剂中，加入氟化钾和KCoF进行氟化反应，得到2-溴-5-氟三氟甲苯。本发明以三氟甲苯为原料，是全新的合成路线，溴化和氟化条件温和，反应产率高，所用的