Process method for preparing acetylthiocholine iodide

The invention discloses a process method for preparing acetylthiocholine iodide, which comprises the following steps: 1) reacting potassium thioacetate used as a raw material with 1,2-dichloroethane under the action of a catalyst to obtain 2-chloroethane thioacetate; 2) reacting the 2-chloroethane thioacetate as a raw material with iodized salt to obtain 2-iodoethane thioacetate; and 3) reacting the 2-iodoethane thioacetate as a raw material with a trimethylamine compound to obtain the acetylthiocholine iodide. The method is high in safety, mild in reaction condition and high in reaction yield. 本发明公开了一种制备碘化乙酰硫代胆碱的工艺方法，包括步骤一：以硫代乙酸钾为原料，与1,2-二氯乙烷在催化剂作用下反应，得到2-氯乙烷硫代乙酸酯；步骤二：以2-氯乙烷硫代乙酸酯为原料，与碘盐反应，得到2-碘乙烷硫代乙酸酯；步骤三：以2-碘乙烷硫代乙酸酯为原料，与三甲胺类化合物反应，得到碘化乙酰硫代胆碱。其安全性高，反应条件温和，反应收率高。