Refining method of cyclobenzaprine hydrochloride
The invention discloses a refining method of cyclobenzaprine hydrochloride, and concretely relates to the field of medicines. The refining method comprises the following preparation steps: S1, in an extraction process in the later period of cyclobenzaprine hydrochloride processing, adding dispersed...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a refining method of cyclobenzaprine hydrochloride, and concretely relates to the field of medicines. The refining method comprises the following preparation steps: S1, in an extraction process in the later period of cyclobenzaprine hydrochloride processing, adding dispersed adsorption powder into a mixed solution of cyclobenzaprine hydrochloride, stirring by adopting a paddle stirrer, and precipitating to obtain a cyclobenzaprine hydrochloride crude product; S2, adding an organic solvent into the cyclobenzaprine hydrochloride crude product, performing recrystallization, dissolving and stirring in a steam pressurizing manner, and keeping constant temperature for later use; and S3, filtering and adsorbing the mixed solution obtained in step S2 through vesuvianite, and filtering to obtain a white refined cyclobenzaprine hydrochloride product. By adding the dispersed adsorption powder, crystals can be dispersed and fluffy, impurity byproducts are not wrapped, crystal discharging is fine a |
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