Amino acid racemase and application thereof

The invention discloses an amino acid racemase and application of the amino acid racemase in amino acid racemization catalysis, and belongs to the biotechnology field. The amino acid racemase is polypeptide I of which the amino acid sequence is disclosed by SEQ ID NO.1 or polypeptide II which has at least 70% identity with the amino acid sequence disclosed by SEQ ID NO.1 and has an amino acid racemization catalysis function. The amino acid racemase has racemization activity for various amino acid isomers, including Leu, Met and the like, and also has thermal stability, and the amino acid racemase can be applied to the racemization of enzyme catalysis L-Leu/ D-Leu, and L-met/ D-Met, and has an important meaning for realizing the mutual transformation of amino acid enantiomers. 本发明公开了一种氨基酸消旋酶及其在催化氨基酸消旋中的应用，属于生物技术领域。所述氨基酸消旋酶为氨基酸序列如SEQ ID NO.1所示的多肽Ⅰ或与SEQ ID NO.1所示氨基酸序列具有至少70％同一性且具有催化氨基酸消旋功能的多肽Ⅱ，所述氨基酸消旋酶对Leu、Met等多种氨基酸异构体具有消旋活性，且具有热稳定性，可将其应用到酶催化L-Leu/D-Leu、L-Met/D-Met的消旋化，对于实现氨基酸对映体的相互转化具有重要意义。