Synthesis method of cobamamide

The invention discloses a synthesis method of cobamamide, and belongs to the technical field of production of vitamin B12 series products. The cobamamide is prepared by adopting a chemical synthesis method based on cyanocobalamin, sodium borohydride and adenosine triphosphate, and then the cobamamide is further refined and purified to obtain the cobamamide finished product. According to the process, the yield of cobamamide can be greatly increased from about 50% to 99% or above. 本发明公开了一种腺苷钴胺合成方法，属于维生素B12系列产品生产技术领域。本发明采用基于氰钴胺、硼氢化钠、腺嘌呤核苷三磷酸的化学合成法制备腺苷钴胺，然后再进一步精制提纯，进而得到腺苷钴胺成品。此工艺能够使腺苷钴胺的收率大大提高，由之前的50％左右提高到99％以上。