Doxazosin mesylate crystal form, preparation method and application thereof

The invention provides a doxazosin mesylate crystal form, a preparation method and application thereof, wherein the new crystal form has X-ray diffraction peaks when the 2[theta] (+/-0.20 [theta]) angle is 6.800 DEG, 11.662 DEG, 17.719 DEG, 23.961 DEG and 25.981 DEG. According to the invention, the preparation method of the crystal form is simple, conditions in industrial production are easy to control, a simple and feasible method is provided for preparation of the metastable crystal form, the new crystal form has good stability and good dissolution rate, and the new crystal form has strong application advantages in the field of sustained and controlled release oral preparations as anew metastable crystal form. 本发明提供了一种多沙唑嗪甲磺酸盐晶型、其制备方法及用途，该新晶型在2θ(±0.20θ)角位于6.800°、11.662°、17.719°、23.961°、25.981°处具有X-射线衍射峰，该晶型的制备方法简单，在工业生产中条件容易控制，本发明为亚稳晶型的制备提供了一种较为简易可行的方法，新晶型具有良好的稳定性和溶出度，且该新晶型作为一种新的亚稳晶型将在缓控释口服制剂领域有着较强的应用优势。