Allyl ketone derivative of enrofloxacin, preparation method and application thereof

The invention discloses an enrofloxacin acrylketone derivative, a preparation method and application thereof, wherein a chemical structural general formula represented by a formula I is adopted,, andin the formula I, an aromatic ring Ar is a benzene ring or a substituted benzene ring or a furan ring or a pyridine ring. According to the invention, a fluoroquinolone skeleton and an acrylketone skeleton are effectively spliced to construct a novel fluoroquinolone chalcone-like compound, so that the antitumor activity and the drug resistance of the novel compound are improved, the toxic and sideeffects on normal cells are reduced, and the novel fluoroquinolone chalcone-like compound can be used as an anti-tumor active substance to develop an anti-tumor drug with a brand-new structure. 本发明公开了一种恩诺沙星的丙烯酮衍生物及其制备方法和应用，采用如下式Ⅰ化学结构通式：式I中，芳香环Ar为苯环或取代苯环或呋喃环或吡啶环。本发明的一种恩诺沙星的丙烯酮衍生物，实现了氟喹诺酮骨架与丙烯酮骨架的有效拼合，进而构筑了新的氟喹诺酮"类查尔酮"化合物，从而增加了新化合物的抗肿瘤活性及抗耐药性，并降低对正常细胞的毒副作用，可以作为抗肿瘤活性物质开发全新结构的抗肿瘤药物。