Paracetamol tablet and preparation method thereof

The invention discloses a paracetamol tablet. The paracetamol tablet is composed of paracetamol, a filler, a binder, a disintegrating agent, a lubricant and a stabilizer, wherein when an appropriate amount of stabilizer is added into the binder, the stability of the dissolution rate can be significa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: WANG ZHIFENG, LIU HUINIAN, AN YUJIE, BAO ZHENGXUE, BAO YULI, SU HAIYAN
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a paracetamol tablet. The paracetamol tablet is composed of paracetamol, a filler, a binder, a disintegrating agent, a lubricant and a stabilizer, wherein when an appropriate amount of stabilizer is added into the binder, the stability of the dissolution rate can be significantly improved. The invention also discloses a preparation method of the paracetamol tablet. The method uses a micronization technology to process the raw and auxiliary materials, so that the fusion of the raw and auxiliary materials can be improved, the tabletting time can be shortened, and the production costs can be saved. The finally prepared paracetamol tablet has a bright and clean appearance, a high dissolution rate, good stability and easy storage, and is suitable for large-scale industrial production. 本发明公开了一种对乙酰氨基酚片,该对乙酰氨基酚片由对乙酰氨基酚与填充剂、粘合剂、崩解剂、润滑剂及稳定剂组成,其中粘合剂中加入适量稳定剂能显著提高其溶出度稳定性。本发明还公开了对乙酰氨基酚片的制备方法,采用微粉化技术对原辅料进行处理,提高原辅料的融合性,缩短压片时间,节约生产成本。最终制得的对乙酰氨基酚片外观光洁、溶出度高、稳定性好、易于贮存,适用于工业化大生产。