Preparation method and application of chitosan-sodium alginate hydrogel
The invention provides a preparation method and an application of chitosan-sodium alginate hydrogel. The chitosan-sodium alginate hydrogel provided by the invention is used as a medicine carrying carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and high...
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| creator | ZHAN WEIGUO |
| description | The invention provides a preparation method and an application of chitosan-sodium alginate hydrogel. The chitosan-sodium alginate hydrogel provided by the invention is used as a medicine carrying carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and high crosslinking degree, the carrier hydrogel has a two-phase group having a high affinity for a livingbody, the sodium alginate has acid decomposition resistance, chitosan is automatically degraded in an acidic environment, sodium alginate enables the chitosan-sodium alginate hydrogel to be slowly unlinked under a meta-acidic condition to release internally loaded drugs, the action time of the drugs is prolonged, the action effect of the drugs is improved, and it is indicated that the chitosan-sodium alginate hydrogel has wide substantive application as a new drug-loading carrier hydrogel.
本发明提供了一种壳聚糖-海藻酸钠水凝胶的制备和应用，本发明提供的壳聚糖-海藻酸钠水凝胶作为载药载体，具有合成方法简单、包封率高，交联度高等特点，本发明的载体水凝胶具有对生物体亲和性高的两相基团，海藻酸钠具有抗酸性分解的性能，壳聚糖在酸性环境中自动降解，海藻酸钠 |
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本发明提供了一种壳聚糖-海藻酸钠水凝胶的制备和应用，本发明提供的壳聚糖-海藻酸钠水凝胶作为载药载体，具有合成方法简单、包封率高，交联度高等特点，本发明的载体水凝胶具有对生物体亲和性高的两相基团，海藻酸钠具有抗酸性分解的性能，壳聚糖在酸性环境中自动降解，海藻酸钠</description><language>chi ; eng</language><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS ; DERIVATIVES THEREOF ; GENERAL PROCESSES OF COMPOUNDING ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; WORKING-UP</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200612&DB=EPODOC&CC=CN&NR=111269332A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200612&DB=EPODOC&CC=CN&NR=111269332A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHAN WEIGUO</creatorcontrib><title>Preparation method and application of chitosan-sodium alginate hydrogel</title><description>The invention provides a preparation method and an application of chitosan-sodium alginate hydrogel. The chitosan-sodium alginate hydrogel provided by the invention is used as a medicine carrying carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and high crosslinking degree, the carrier hydrogel has a two-phase group having a high affinity for a livingbody, the sodium alginate has acid decomposition resistance, chitosan is automatically degraded in an acidic environment, sodium alginate enables the chitosan-sodium alginate hydrogel to be slowly unlinked under a meta-acidic condition to release internally loaded drugs, the action time of the drugs is prolonged, the action effect of the drugs is improved, and it is indicated that the chitosan-sodium alginate hydrogel has wide substantive application as a new drug-loading carrier hydrogel.
本发明提供了一种壳聚糖-海藻酸钠水凝胶的制备和应用，本发明提供的壳聚糖-海藻酸钠水凝胶作为载药载体，具有合成方法简单、包封率高，交联度高等特点，本发明的载体水凝胶具有对生物体亲和性高的两相基团，海藻酸钠具有抗酸性分解的性能，壳聚糖在酸性环境中自动降解，海藻酸钠</description><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</subject><subject>DERIVATIVES THEREOF</subject><subject>GENERAL PROCESSES OF COMPOUNDING</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAPKEotSCxKLMnMz1PITS3JyE9RSMwD4oKCnMxkiHB-mkJyRmZJfnFinm5xfkpmaa5CYk56Zl5iSapCRmVKUX56ag4PA2taYk5xKi-U5mZQdHMNcfbQTS3Ij08tLkhMTs1LLYl39jM0NDQyszQ2NnI0JkYNAKLvNGI</recordid><startdate>20200612</startdate><enddate>20200612</enddate><creator>ZHAN WEIGUO</creator><scope>EVB</scope></search><sort><creationdate>20200612</creationdate><title>Preparation method and application of chitosan-sodium alginate hydrogel</title><author>ZHAN WEIGUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111269332A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</topic><topic>DERIVATIVES THEREOF</topic><topic>GENERAL PROCESSES OF COMPOUNDING</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHAN WEIGUO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHAN WEIGUO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method and application of chitosan-sodium alginate hydrogel</title><date>2020-06-12</date><risdate>2020</risdate><abstract>The invention provides a preparation method and an application of chitosan-sodium alginate hydrogel. The chitosan-sodium alginate hydrogel provided by the invention is used as a medicine carrying carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and high crosslinking degree, the carrier hydrogel has a two-phase group having a high affinity for a livingbody, the sodium alginate has acid decomposition resistance, chitosan is automatically degraded in an acidic environment, sodium alginate enables the chitosan-sodium alginate hydrogel to be slowly unlinked under a meta-acidic condition to release internally loaded drugs, the action time of the drugs is prolonged, the action effect of the drugs is improved, and it is indicated that the chitosan-sodium alginate hydrogel has wide substantive application as a new drug-loading carrier hydrogel.
本发明提供了一种壳聚糖-海藻酸钠水凝胶的制备和应用，本发明提供的壳聚糖-海藻酸钠水凝胶作为载药载体，具有合成方法简单、包封率高，交联度高等特点，本发明的载体水凝胶具有对生物体亲和性高的两相基团，海藻酸钠具有抗酸性分解的性能，壳聚糖在酸性环境中自动降解，海藻酸钠</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP |
| title | Preparation method and application of chitosan-sodium alginate hydrogel |
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