N-cyclohexyl-furan-2-formamide compound as well as preparation method and application thereof

The invention discloses an N-cyclohexyl-furan-2-formamide compound as well as a preparation method and application of the N-cyclohexyl-furan-2-formamide compound. The N-cyclohexyl-furan-2-formamide compound can be used for preparing an anti-schizophrenia drug SIPI6398, and has the following remarkab...

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Hauptverfasser: CHEN XIAOWEN, LI JIANQI, SU XIAOJING, PU QIANG, QI YANGLI, ZHOU AINAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an N-cyclohexyl-furan-2-formamide compound as well as a preparation method and application of the N-cyclohexyl-furan-2-formamide compound. The N-cyclohexyl-furan-2-formamide compound can be used for preparing an anti-schizophrenia drug SIPI6398, and has the following remarkable advantages compared with the prior art and reported literatures: 1, when the N-cyclohexyl-furan-2-formamide compound disclosed by the invention is used for synthesizing the SIPI6398 without the need of a reaction process of connecting a protecting group and removing the protecting group so that atom economy is high; 2, when the N-cyclohexyl-furan-2-formamide compound is used for preparing SIPI6398, the raw materials are cheap and easy to obtain, the cost is low, the reaction conditions are mild, the yield is stable, the operation is simple and convenient, the three-waste pollution is little, and the industrial production is easy, and the N-cyclohexyl-furan-2-formamide compound is a compound with the following st