PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Disclosed are a pyrimidine compound, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a pyrimidine compound represented by the general formula(I), and a preparation method therefor, and the use of same as an inhibitor of cyclin-dependent kina...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FAN PINGPING, ZHANG LIYUN, LI JIAYAN, SI JUTONG, JIANG MEIFENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are a pyrimidine compound, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a pyrimidine compound represented by the general formula(I), and a preparation method therefor, and the use of same as an inhibitor of cyclin-dependent kinase 7 (CDK7), particularly the use in preventing and/or treating human diseases including cancers. Definitions of each group in the general formula (I) are as defined in the description. 一种嘧啶类化合物、其制备方法及其医药用途。具体而言，涉及一种通式(I)所示的嘧啶类化合物，及其制备方法，以及其作为细胞周期蛋白依赖性激酶7(CDK7)抑制剂的用途，特别是在预防和/或治疗人类疾病包括癌症中的用途。其中，通式(I)中各基团的定义与说明书中的定义相同。