USE OF SYNCYTIN FOR TARGETING DRUG AND GENE DELIVERY TO REGENERATING MUSCLE TISSUE

The invention relates to a pharmaceutical composition for targeting drug delivery including gene delivery to regenerating muscle tissue, comprising at least a therapeutic drug or gene, associated to asyncytin protein, and its use in the prevention and/or treatment of muscle injuries or diseases, in...

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Bibliographische Detailangaben
Hauptverfasser:	FERRAND MAXIME, GALY ANNE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a pharmaceutical composition for targeting drug delivery including gene delivery to regenerating muscle tissue, comprising at least a therapeutic drug or gene, associated to asyncytin protein, and its use in the prevention and/or treatment of muscle injuries or diseases, in particular in gene therapy of said diseases using lentiviral vector particles or lentivirus-like particles pseudotyped with syncytin protein. 本发明涉及将药物靶向递送(包括基因递送)至再生肌肉组织的药物组合物，其至少包含与合胞素蛋白结合的治疗性药物或基因，及其在预防和/或治疗肌肉损伤或疾病中的用途，特别是在使用用合胞素蛋白假型化的慢病毒载体颗粒或慢病毒样颗粒基因治疗所述疾病中的用途。