PHARMACEUTICAL FORMULATIONS COMPRISING OPIOID RECEPTOR AGONIST AS ACTIVE INGREDIENTS, METHODS OF MANUFACTURE AND THERAPEUTIC USES THEREOF

The present invention concerns a pharmaceutical formulation in form of aqueous solution for sublingual and buccal administration, for the treatment of neonatal abstinence syndrome, said formulation comprising buprenorphine or a pharmaceutically acceptable salt thereof as the sole active ingredient, a viscosity enhancer, and a buffering agent in an amount to provide a pH of from 5.0 to 7.0. 本发明涉及用于舌下和含服施用的呈水溶液形式的药物制剂，其用于治疗新生儿戒断综合征，所述制剂包含丁丙诺啡或其药学上可接受的盐作为唯一活性成分、粘度增强剂和提供5.0-7.0的pH的量的缓冲剂。