Moist heat sterilization method of citicoline and sodium salt injection thereof

The invention provides a moist heat sterilization method of citicoline and a sodium salt injection thereof. The method comprises a pulsation vacuum sterilization procedure, a steam-air mixture sterilization procedure, and a superheated water sterilization procedure, wherein the pulsation vacuum sterilization procedure uses a pulsation vacuum sterilizer for sterilization; the steam-air mixture sterilization procedure uses a steam-air mixed sterilizer for sterilization; and the superheated water sterilization procedure uses a high-pressure superheated water spray sterilizer for sterilization. The moist heat sterilization method of citicoline and a sodium salt injection thereof minimizes the degradation of a pharmaceutical component during the sterilization process, and improves the safety ofthe medicine on the basis of fully ensuring the sterilization effect. 本发明提供一种胞磷胆碱及其钠盐注射液的湿热灭菌方法，包括脉动真空灭菌程序、蒸汽-空气混合物灭菌程序、过热水灭菌程序；其中，所述脉动真空灭菌程序采用脉动真空灭菌器进行灭菌；所述蒸汽-空气混合物灭菌程序采用混合蒸汽-空气灭菌器进行灭菌；所述过热水灭菌程序采用高压过热水喷淋灭菌器进行灭菌。本发明所述的胞磷胆碱及其