Simple preparation method of bromfenac sodium

The invention relates to a simple preparation method of bromfenac sodium, comprising the following steps: carrying out a condensation reaction between bromophenylacetonitrile and 2-nitrophenylacetic acid under the action of alkali to prepare 7-(4-bromophenyl)-3-carboxymethylbenzo [c] isoxazole (IV), carrying out a reduction reaction on the compound as shown in the formula IV, and alkalizing with sodium hydroxide for salifying to prepare bromfenac sodium. The method has the advantages of cheap and easily available raw materials, simple route, easy operation, low product cost, good product purity and high yield, and is suitable for industrial production. 本发明涉及一种溴芬酸钠的简便制备方法，该方法利用对溴苯乙腈和2-硝基苯乙酸于碱作用下经缩合反应制备7-(4-溴苯基)-3-羧基甲基苯并[c]异噁唑(Ⅳ)，然后所得式Ⅳ化合物经还原反应、氢氧化钠碱化成盐制备溴芬酸钠。该方法原料价廉易得，路线简便，易于操作，所得产品成本低，产物纯度好和收率高，适于工业化生产。