Preparation method of 3-piperidine-2-yl-azetidine-3-ol derivative

The invention discloses a preparation method of a 3-piperidine-2-yl-azetidine-3-ol derivative, which comprises the following steps: adopting a compound disclosed in the invention as a starting material, sequentially carrying out a three-membered ring forming reaction, a protecting group adding reaction, a ring opening reaction, a substitution reaction, an addition reaction and a cyclization reaction to obtain the 3-piperidine-2-yl-azetidine-3-ol derivative. The preparation method of the 3-piperidine-2-yl-azetidine-3-ol derivative has the advantages of simple operation, mild reaction conditions, high yield, few impurities and the like, is easy to amplify, and is suitable for industrial production. 本发明公开了一种3-哌啶-2-基-氮杂环丁烷-3-醇衍生物的制备方法，包括以下步骤：以为起始原料，依次进行成三元环反应、上保护基反应、开环反应、取代反应、加成反应和环化反应，即可得到3-哌啶-2-基-氮杂环丁烷-3-醇衍生物。本发明的3-哌啶-2-基-氮杂环丁烷-3-醇衍生物制备方法具有操作简单、反应条件温和、收率高、杂质少等优点，易放大，适于工业化生产。