USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS

The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (V...

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Bibliographische Detailangaben
Hauptverfasser: MURAKAMI RYO, GRAY NATHANAEL S, FISHER DAVID E, LIANG YANKE, CHOI HWAN GEUN, MUJAHID NISMA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (VII). Also provided are pharmaceutical compositions, methods, and uses that include or involve a compound described herein. 本公开内容提供了增加有此需要的受试者中的皮肤色素沉着的方法,其使用盐可诱导激酶(SIK)抑制剂,诸如式(I)的大环化合物,式(II)、(III)和(IV)的双环脲化合物,和式(V),(VI),(VI-A)或(VII)的化合物。还提供了包括或牵涉本文中所述的化合物的药物组合物、方法和用途。