Quadruple vaccine for poultry and preparation method and application thereof

The present invention relates to a quadruple vaccine for poultry and a preparation method and an application thereof. The quadruple vaccine for the poultry is for chicken Newcastle disease, H9 subtypeavian influenza, infectious bursal disease and avian adenovirus disease. Inactivated chicken Newcast...

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Hauptverfasser: YAO RONG, BAI HONGYING, WANG XIN, ZHANG LIHUA, ZHOU MINGGUANG, SU XIUCHAN, CHENG TAILANG, XU GAOYUAN, MING FAN, GAO SHANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to a quadruple vaccine for poultry and a preparation method and an application thereof. The quadruple vaccine for the poultry is for chicken Newcastle disease, H9 subtypeavian influenza, infectious bursal disease and avian adenovirus disease. Inactivated chicken Newcastle disease virus La Sota strain, inactivated H9 subtype avian influenza virus HB01 strain, infectious bursal disease virus capsid protein VP2 and avian adenovirus structural protein Fiber2 are mixed to prepare an oil-water emulsion. The provided quadruple vaccine for the poultry has high safety, good stability and long duration of immune protection, can provide long-lasting maternal antibodies to the offspring young chicken after immunization of hens, and is extremely low in endotoxin content and small in immune side reactions. In addition, the four antigens have good compatibility, competition and expression inhibition between the different antigens do not exist, and the four components inthe quadruple vaccine for