PREFILLED SYRINGE AND METHOD OF PREPARING A PREFILLED SYRINGE

A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111),and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle ad...

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Bibliographische Detailangaben
Hauptverfasser:	FELSOVALYI FLORA, CHRISTENSEN DENNY, BOWEN MAYUMI, HEMMINGER MARKUS, GRAUSCHOPF ULLA, BAMBERG FRANK, MULLER ROBERT
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CONVEYING DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HANDLING THIN OR FILAMENTARY MATERIAL HUMAN NECESSITIES HYGIENE MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS MEDICAL OR VETERINARY SCIENCE PACKING PERFORMING OPERATIONS STORING TRANSPORTING UNPACKING
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Beschreibung
Zusammenfassung:	A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111),and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle adaptor cap (12) has a rubber element (121) tightly sealing the orifice (113) of the tip (112) of thesyringe barrel (11) and the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) is sterilized by a first sterilizing comprising a mainstep of exposing the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 5 hours to about 60 hours at a relative humidity of about 40% to about 100% and at a temperature of about 30degrees to about 60degrees; (ii) filling a drug substance (14) through the open end (111) of the syringe barrel (11) into an interior of the syringe barre