Method for reducing nitrocompound through biocatalysis

The invention provides a method for reducing nitrocompound through biocatalysis. A coenzyme is used as a hydrogen donor, olefin reductase is used as a catalyst, the nitrocompound is subjected to catalytic reduction, and a hydroxylamine compound or an amine compound is generated. The method for reduc...

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Bibliographische Detailangaben
Hauptverfasser: LI RENJIE, MENG XIAO, YUE YONGTANG, ZHOU JIANGUANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a method for reducing nitrocompound through biocatalysis. A coenzyme is used as a hydrogen donor, olefin reductase is used as a catalyst, the nitrocompound is subjected to catalytic reduction, and a hydroxylamine compound or an amine compound is generated. The method for reducing the nitrocompound through biocatalysis provided by the invention replaces a conventional methodfor chemically reducing the nitrocompound which is complex, dangerous and polluted in product extraction, the olefin reductase which can be obtained through purchase from the market or prepared by oneself is used as the catalyst, and a quick, simple and effective scheme for reducing the nitrocompound by a biocatalysis method can be established; and the nitrocompound is reduced into the stable hydroxylamine compound or the amine compound, the method has broad substrate applicability, and a high-flux and rapid nitroreduction reaction can be realized. 本发明提供的一种生物催化还原硝基化合物的方法,以辅酶作为氢供体,以烯烃还原酶作为催化剂,催化还原硝基化合物,生成羟胺化合物或胺化合物。本发明