Quinolizinone compound and preparation method thereof

The invention relates to a quinolizinone compound and a preparation method thereof, belonging to the technical field of organic chemical synthesis. The molecular structural formula of the quinolizinone compound disclosed in the invention is as shown in the specification. The preparation method compr...

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Bibliographische Detailangaben
Hauptverfasser: FANG JIWANG, GONG HANYUAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a quinolizinone compound and a preparation method thereof, belonging to the technical field of organic chemical synthesis. The molecular structural formula of the quinolizinone compound disclosed in the invention is as shown in the specification. The preparation method comprises the following steps: with an alkyne ester propiolate compound as a raw material, adding a pyridine derivative into the raw material, adding ethyl acetate into the formed mixture, adding alkali, performing a reaction at a proper temperature, conducting cooling to room temperature, carrying out reduced-pressure distillation to remove a solvent in a reaction product, performing washing with water multiple times to remove an inorganic salt in the reaction product, and carrying out collecting byadopting a column chromatography method to obtain the quinolizinone compound. According to the method, raw materials required by the reaction are easy to obtain, yield is high, reaction conditions are mild, reaction time is