Process method for producing 2, 6-difluorobenzamide

The invention discloses a process method for producing 2, 6-difluorobenzamide, which is characterized in that 2, 3-dichloronitrobenzene and cuprous cyanide are used as raw materials, N-methyl pyrrolidone is used as a solvent, 2-chloro-6-nitrobenzonitrile is synthesized, the prepared 2-chloro-6-nitro...

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Bibliographische Detailangaben
Hauptverfasser: YIN LIANQI, YANG XIANGDANG, XU JIANCHANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a process method for producing 2, 6-difluorobenzamide, which is characterized in that 2, 3-dichloronitrobenzene and cuprous cyanide are used as raw materials, N-methyl pyrrolidone is used as a solvent, 2-chloro-6-nitrobenzonitrile is synthesized, the prepared 2-chloro-6-nitrobenzonitrile is dissolved in an N, N-dimethylformamide solvent, then tetramethylammonium fluoride isadded so as to prepare 2, 6-difluorobenzonitrile, a sodium hydroxide solution is added into the prepared 2, 6-difluorobenzamide, and hydrogen peroxide is dropwisely added for hydrolysis to obtain a finished product 2, 6-difluorobenzamide. According to the process, 2, 3-dichloronitrobenzene and cuprous cyanide are used as raw materials, and the production cost of the product is effectively reducedthrough a process method of raw material chain stretching, potassium fluoride is replaced by tetramethylammonium fluoride in the fluorination reaction, so that the reaction temperature can be reduced, a catalyst is not needed