Preparation method of metoprolol intermediate

The invention provides a preparation method of a metoprolol intermediate, and belongs to the field of drug synthesis. The preparation method specifically comprises the following steps: etherifying p-chlorophenol under the action of dimethyl sulfate and sodium hydroxide to obtain p-chloroanisole; reacting the p-chloroanisole with ethylene oxide under the condition of magnesium catalysis to obtain p-methoxyphenylethanol; and reacting the p-methoxyphenylethanol with dimethyl carbonate in a toluene solvent, and adding dilute sulfuric acid for hydrolysis to obtain the metoprolol intermediate p-(2-methoxy)ethyl phenol. The preparation method has the advantages of cheap and easily available raw materials, simple process steps, and convenience in operation, and is suitable for industrial production. 本发明提供了一种美托洛尔中间体的制备方法，属于药物合成领域。本发明提供的制备方法具体为：对氯苯酚在硫酸二甲酯、氢氧化钠作用下，醚化得对氯苯甲醚；对氯苯甲醚在镁催化条件下，与环氧乙烷反应得到对甲氧基苯乙醇；对甲基苯乙醇在甲苯溶剂中，与碳酸二甲酯反应，在加入稀硫酸水解，得到美托洛尔中间体对(2-甲氧基)乙基苯酚。该制备方法原料廉价易得，工艺步骤简单，操作方便，适合工业化生产。