Preparation method of nuclide molecular probe targeting CD4 receptor and application of nuclide molecular probe serving as heart transplant rejection reaction imaging agent

The invention relates to a preparation method of a nuclide molecular probe targeting a CD4 receptor and an application of the nuclide molecular probe serving as a heart transplant rejection reaction imaging agent. The method comprises the following steps: mixing leukocyte differentiation antigen 4 monoclonal antibody with a 6-hydrazino nicotinoyl succinimide ester hydrochloride solution, performing extraction reaction to obtain 6-hydrazino nicotinamide-leukocyte differentiation antigen 4 monoclonal antibody, mixing the 6-hydrazinonicotinamide-leukocyte differentiation antigen 4 monoclonal antibody with N-tri (hydroxymethyl) methylglycine, stannous chloride and technetium, and performing oscillation reaction; the beneficial effects is as follows: higher marking rate and radiochemical puritycan be obtained, and good affinity to CD4 + T lymphocytes can be obtained; as a transplant rejection reaction imaging agent, the probe has the characteristics of high sensitivity and high specificity, and can realize early d