Application of deoxyelephantolide or isodeoxyelephantolide in preparation of a medicine used for resisting lung fibrosis

The invention discloses an application of deoxyelephantolide or isodeoxyelephantolide in preparation of a medicine used for resisting lung fibrosis. Researches find that the deoxyelephantolide or theisodeoxyelephantolide can be used for effectively inhibiting the proliferation of human embryonic lung fibroblasts HFL1. Western Blot results show that the proliferation inhibition effect of the deoxyelephantolide or the isodeoxyelephantolide on human embryonic lung fibroblasts HFL1 is likely to be related with the situation that the human embryonic lung fibroblasts is blocked in a G1 phase and can not realize cell division and proliferation through down regulation of the expression of cyclin D1 and CDK4. Therefore, the deoxyelephantolide or the isodeoxyelephantolide has the prospect of beingdeveloped into the medicine used for resisting the lung fibrosis. 本发明公开了一种去氧地胆草内酯或异去氧地胆草内酯在制备抗肺纤维化药物中的应用。本发明研究发现，去氧地胆草内酯或异去氧地胆草内酯可以有效抑制人胚肺成纤维细胞HFL1的增殖，Western Blot结果表明去氧地胆草内酯或异去氧地胆草内酯对人胚肺成纤维细胞HFL1的增殖抑制作用可能与其通过下调细胞周期蛋白Cyclin D1