Colon-targeted sinomenine hydrochloride slow-release nanofiber membrane and preparation method and application thereof

The invention discloses a colon-targeted sinomenine hydrochloride slow-release nanofiber membrane and a preparation method and application thereof. The nanofiber membrane comprises a shell layer and acore layer coated in the shell layer, wherein the shell layer comprises the following components: Eudragit S100 or Eudragit RS100; the core layer comprises the following components: any one or more than two of Eudragit S100, Eudragit RS100, polycaprolactone and polyvinylpyrrolidone, and sinomenine hydrochloride. The drug loading capacity of sinomenine hydrochloride in the nanofiber membrane is 10%-30%. According to the sinomenine hydrochloride slow-release nanofiber membrane with the shell-core structure, slow release and targeting of the drug are realized and the membrane has good biocompatibility. 本发明公开了一种结肠靶向盐酸青藤碱缓释纳米纤维膜及其制备方法和应用，该纳米纤维膜包含：壳层和包覆在壳层内的核层；其中，所述壳层的成分包含：Eudragit S100或Eudragit RS100；所述核层的成分包含：Eudragit S100、Eudragit RS100、聚己内酯和聚乙烯吡咯烷酮中任意一种或两种以上，和盐酸青藤碱；该纳米纤维膜中盐酸青藤碱的载药量为10％～30％。本发明的制备壳-核结构盐酸青藤碱缓释纳米纤维膜，使