GASTRORETENTIVE DOSAGE FORMS FOR SUSTAINED DRUG DELIVERY

The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity. 本公开内容涉及具有延长的胃滞留时间的漂浮的胃滞留剂型。本公开内容还提供快速膨胀的缓释或组合的立即释放和缓释制剂，其包含需要在近端胃肠道中靶向释放以实现最大治疗益处的药物。快速膨胀的漂浮的胃滞留剂型包括可渗透的弹性膜，所述膜为药物释放和机械强度提供了所需的特性，以保持片剂的完整性。