Method for preparing thioether conjugates

A method is provided for preparing thioether conjugates useful in treating neoplastic diseases and preferably formed of the BR96 immunoconjugate synthesized from a heterobifunctional linker of doxorubicin, wherein a purified and reduced form of BR96 MAb is conjugated with the 6-maleimidocaproyl hydr...

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Bibliographische Detailangaben
Hauptverfasser:	YADAGIRI PENDRI, JOHN K. THOTTATHIL, KUMAR G. GADAMASETTI
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A method is provided for preparing thioether conjugates useful in treating neoplastic diseases and preferably formed of the BR96 immunoconjugate synthesized from a heterobifunctional linker of doxorubicin, wherein a purified and reduced form of BR96 MAb is conjugated with the 6-maleimidocaproyl hydrazone of doxorubicin and the resulting crude conjugate is purified.